Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation
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VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans
The complex molecular and cellular mechanisms underlying neuronal control of animal movement are not well understood. Locomotion of Caenorhabditis elegans is mediated by a neuronal circuit that produces coordinated sinusoidal movement. Here we utilize this simple, yet elegant, behaviour to show that VAV-1, a conserved guanine nucleotide exchange factor for Rho-family GTPases, negatively regulat...
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تاریخ انتشار 2015